Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE Upregulation of COX-2 in the lung cancer promotes overexpression of multidrug resistance protein 4 (MRP4) via PGE2-dependent pathway. 24909729

2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE Tumor cell expression of COX-2 has been implicated in the progression of murine and human lung cancer. 15825163

2005
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells. 21461558

2011
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE To assess the impact of COX-2 expression in lung cancer invasiveness, NSCLC cell lines were transduced with a retroviral vector expressing the human COX-2 cDNA in the sense (COX-2-S) and antisense (COX-2-AS) orientations. 11320076

2001
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 GeneticVariation BEFREE TNF-α 308G/A, IL-6 174G/C, IL-1β 31T/C, IL-1β 511C/T, COX-2 8473T/C polymorphisms were not detected to be related to the risk for LC. 22160576

2012
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE Tissue microarray immunohistochemical analysis was performed to assess the correlation between NMI and COX-2 expression in lung cancer patients. 29025423

2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Thus, COX-2 is likely important in lung tumorigenesis, and COX-2 and its product, PGE2, are potential targets for lung cancer prevention. 26452035

2015
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE This is the first description of functional COX-2 expression by NSCLC cells and the definition of a pathway whereby tumor COX-2 expression and a high level of PGE2 production mediate profound alteration in cytokine balance in the lung cancer microenvironment. 9515807

1998
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE These results show that the inhibition of COX-2 expression by UG transduction correlated with the suppression of NF-kappaB activity in the lung cancer cells. 15829319

2005
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 GeneticVariation BEFREE These findings indicate that the COX-2 T8473C polymorphism may contribute to lung cancer susceptibility in the Chinese population. 15777967

2005
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 GeneticVariation BEFREE There was interaction between IL-1B T-31C, COX-2 A-1195G and PPARgamma2 Pro(12)Ala and NSAID use in relation to lung cancer risk. 18164040

2008
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE The THP-1, monocytic leukemia cell line effectively absorbed COX-2 by lung cancer cell-derived exosomes. 29345286

2018
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE TGF-β1 downregulates COX-2 expression leading to decrease of PGE2 production in human lung cancer A549 cells, which is involved in fibrotic response to TGF-β1. 24098479

2013
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 GeneticVariation BEFREE Taken together, this meta-analysis suggests that the COX 2 T8473C polymorphism is not associated with lung cancer risk. 22292629

2011
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE Since lung cancer patients were recruited mostly among smokers, who also have been found to exhibit significantly higher infection rate of Helicobacter pylori (HP) infection than non-smokers and, as since the HP-infected subjects show enhanced plasma levels of gastrin, we decided 1) to compare the seroprevalence of HP and the expression of its cytotoxin, CagA, in lung cancer patients with those in the age- and gender-matched controls without cancer: 2) to determine the gene expression for gastrin and its receptors (CCKB-R) in lung cancer, 3) to assess the gastrin levels in plasma bronchial lavage and in tumor tissue and 4) to examine the expression of cyclooxygenase (COX)-1 and COX-2 in cancer tissue resection margin and intact bronchial mucosa. 11208460

2001
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Role of LKB1-CRTC1 on glycosylated COX-2 and response to COX-2 inhibition in lung cancer. 25465874

2015
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE p38 MAPK, ERK, and COX-2 activation are novel mediators for the galectin-1-promoted tumor progression and chemoresistance in lung cancer. 22696230

2012
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Our study provides pharmacological evidence that CS-6 exhibits potential use in the treatment of COX-2-mediated diseases such as lung cancer. 25175164

2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Our findings imply that a COX-2 inhibitor might improve the prognosis of patients with lung cancer through the reduction of G-CSF or GM-CSF. 12708493

2003
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE Moreover, downregulation of COX-2/PGE2 and MIG-7 significantly prolonged the overall and disease-free survival of lung cancer-bearing mice. 25004182

2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE MiR-26b suppresses tumor cell proliferation, migration and invasion by directly targeting COX-2 in lung cancer. 26744864

2015
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 AlteredExpression BEFREE Interestingly, COX-2 is overexpressed in numerous cancers, including lung cancer. 25047043

2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells. 31231223

2019
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Inhibition of COX-2 and EGFR by Melafolone Improves Anti-PD-1 Therapy through Vascular Normalization and PD-L1 Downregulation in Lung Cancer. 30591531

2019
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib. 23943857

2013